Contact us: biosensor@bk.ru

Dr. Rawil F. Fakhrullin's Research Group

Novel materials, such as various types of nanoparticles, nanotubes and their aggregates, especially of biological origin, are a promising tool in the areas of biological imaging, sensing and functionalization. Our group is developing novel colloidal microcapsules and planar thin films aiming to produce biosensors, means for plants protection and drug carriers with controlled release rate. We focus mainly on a variety of biological polymers and colloidal particles as components of thin films as coatings on planar and spherical surfaces. A special attention is given to coating of various living cells with polymer multilayers and nanoparticles (including gold, silver, magnetic and carbon nanospheres and nanotubes).

In our research we use optical, fluorescent and electron microscopy, surface characterization techniques (atomic force microscopy,  electron microscopy), X-ray powder diffractometry and quartz crystal microbalance microgravimetry for adsorption measurements as well as general biochemical and microbiological techniques (gel electrophoresis, chromatography, etc.).

As a part of the Department of Biochemistry, we offer a range of BSc and MSc degree research projects (combined with taught BSc and MSc programs of the Department of Biochemistry). Students working within our group are given a good opportunity to be involved in interdisciplinary research projects and to get acquainted with modern experimental techniques, in addition, students take part in international and national scientific conferences and summer schools. Our group welcomes international students! We are trying to be the friendliest research group at the Department of Biochemistry, and, perhaps, in Kazan State University.

Our group has strong international links with V.N. Paunov’s Group (Colloid and Surfactant Group at the Department of Chemistry, University of Hull, England) and with Nanobiotechnology Center, Yeditepe University, Istanbul, Turkey.

Our research highlighted by the Royal Society of Chemistry : “Introducing cellosomes” by Alexandra Haywood, Chemical Science, 19 May 2009

Our research highlighted by the Royal Society of Chemistry : “Magnetic yeast cells” by Russell Johnson , Chemical Science, 12 November 2009

Publications:

1. D. Zhang, R.F. Fakhrullin , M. Özmen, H. Wang, J Wang, V.N. Paunov , G. Li, W.E. Huang “Functionalisation of Whole Cell Bacterial Reporters With Magnetic Nanoparticles”, Microb. Biotech., 2010, accepted

2. J. Garcia-Alonso, R.F. Fakhrullin, V. N. Paunov, Z. Shen, J. D. Hardege, N. Pamme, S. J. Haswell, G. M. Greenway “Micro-screening Toxicity System based on Living Magnetic Yeast and Gradient Chips”, Anal. Bioanal. Chem., 2010, accepted

3. R.F. Fakhrullin, M-L. Brandy, O. Cayre, O. D. Velev, V. N. Paunov “Live Celloidosome Structures Based on the Assembly of Individual Cells by Colloid Interactions”, Phys. Chem. Chem. Phys., 2010, DOI: 10.1039/c0cp00131g, Fulltext (Royal Society of Chemistry Publishing)

4. R.F. Fakhrullin, L.V. Shlykova, A.I. Zamaleeva, D.K. Nurgaliev, Y.N. Osin, J. Garcia-Alonso, V.N. Paunov “Interfacing Living Unicellular Algae Cells with Biocompatible Polyelectrolyte-Stabilised Magnetic Nanoparticles”, Macromol. Biosci., 2010, DOI: 10.1002/mabi.201000161 Fulltext (Wiley Online Library)

5. M-L. Brandy, O. Cayre, R.F. Fakhrullin, O. D. Velev, V. N. Paunov “Directed Assembly of Yeast Cells into Living Yeastosomes by Templating Microbubbles”, Soft Matter, 2010, 6, 3494 - 3498. Fulltext (Royal Society of Chemistry Publishing)

6. R.F. Fakhrullin, J. Garcia-Alonso, V.N. Paunov “A Direct Technique for Preparation of Magnetically Functionalised Living Yeast Cells”, Soft Matter, 2010, 6, 391 - 397. Fulltext (Royal Society of Chemistry Publishing)

7. J. Garcia-Alonso, R.F. Fakhrullin, V.N. Paunov “Rapid and Direct Magnetization of GFP-Reporter Yeast for Micro-Screening Systems”, Biosens. Bioelectron, 2010, 25, 1816–1819. Fulltext (Elsevier)

8. A.I. Zamaleeva, I.R. Sharipova, A.V. Porfireva, G.A. Evtugyn, R.F. Fakhrullin “Polyelectrolyte-mediated assembly of multi-walled carbon nanotubes on living yeast cells”, Langmuir, 2010,26 (4), 2671–2679. Fulltext (American Chemical Society Publishing)

9. M. Kahraman, A.I. Zamaleeva, R.F. Fakhrullin, M. Culha “Layer-by-layer Coating of Bacteria with Noble Metal Nanoparticles for Surface-Enhanced Raman Scattering” Anal.Bioanal. Chem., 2009, 395, 2559–2567. Fulltext (Springer, Germany)

10. R.F. Fakhrullin, A.G. Bikmullin, D.K. Nurgaliev “Magnetically Responsive Calcium Carbonate Microcrystals”, ACS Appl. Mater. Interfaces, 2009, 1 (9), 1847–1851. Fulltext (American Chemical Society Publishing, USA) 

11. R.F. Fakhrullin, R. T. Minullina “Hybrid Cellular−Inorganic Core−Shell Microparticles: Encapsulation of Individual Living Cells in Calcium Carbonate Microshells”, Langmuir, 2009, 25 (12), 6617–6621. Fulltext (American Chemical Society Publishing, USA)

12. R.F. Fakhrullin, V.N. Paunov “Fabrication of Living Cellosomes of Rod-like and Rhombohedral Morphologies Based on Magnetically Responsive Templates” Chem. Commun. 2009, 2511-2513. Fulltext (Royal Society of Chemistry Publishing, UK)

13. R.F. Fakhrullin, A.I. Zamaleeva, M.V. Morozov, D.I. Tazetdinova, F.K. Alimova, A.K. Hilmutdinov, R.I. Zhdanov, M. Kahraman, M. Culha “Living fungi cells encapsulated in polyelectrolyte shells doped with metal nanoparticles” Langmuir, 2009, 25 (8), 4628-4634. Fulltext (American Chemical Society Publishing, USA)

14. R.F. Fakhrullin, V.G. Vinter, A.I. Zamaleeva, M.V. Matveeva, R.A. Kourbanov, B.K. Temesgen, D.G. Ishmuchametova, Z.I. Abramova, O.A. Konovalova, M.K. Salakhov "Quartz crystal microbalance immunosensor for the detection of antibodies to double-stranded DNA" Anal. Bioanal. Chem. 2007, 388, 367–375. Fulltext (Springer, Germany)